| Year: | 1921 |
| Team: | Sewanee Tigers |
| Sport: | football |
| Conference: | Southern Intercollegiate Athletic Association |
| Short Conf: | SIAA |
| Record: | 6–2 |
| Conf Record: | 4–2 |
| Head Coach: | John Nicholson |
| Hc Year: | 1st |
| Captain: | C. D. Conway |
| Stadium: | Hardee Field |
The 1921 Sewanee Tigers football team represented during the 1921 college football season as a member of the Southern Intercollegiate Athletic Association (SIAA). The Tigers were led by head coach John Nicholson in his first season and finished with a record of six wins and two losses (6–2 overall, 4–2 in the SIAA).