| Team: | Rock Island Independents |
| Year: | 1921 |
| Record: | 5–2–1 Overall 4–2–1 APFA |
| League Place: | 5th in APFA |
| Coach: | Frank Coughlin and Jimmy Conzelman |
| Stadium: | Douglas Park |
The 1921 Rock Island Independents season was their second completed in the young American Professional Football Association (APFA). The team failed to improve on their previous record against league opponents of 6–2–2, winning only four games.[1] They finished fifth in the league.[2]
| Week | Date | Opponent | Result | Record | |
|---|---|---|---|---|---|
| 1 | October 2 | Detroit Tigers | T 0–0 | 0–0–1 | |
| 2 | October 10 | at Chicago Staleys | L 10–14 | 0–1–1 | |
| 3 | October 16 | at Chicago Cardinals | W 14–7 | 1–1–1 | |
| 4 | October 23 | at Detroit Tigers | W 14–0 | 2–1–1 | |
| 5 | October 30 | at Green Bay Packers | W 13–3 | 3–1–1 | |
| 6 | November 6 | Minneapolis Marines | W 14–3 | 4–1–1 | |
| 7 | November 13 | at Chicago Staleys | L 0–3 | 4–2–1 | |
| – | November 20 | Duluth Knights of Columbus | W 28–0 | 5–2–1 |