| Year: | 1921 |
| Team: | Roanoke Maroons |
| Sport: | football |
| Conference: | Independent |
| Record: | 3–7 |
| Head Coach: | Pinky Spruhan |
| Hc Year: | 8th |
| Stadium: | College Field |
The 1921 Roanoke Maroons football team represented Roanoke College as an independent during the 1921 college football season. Led by eighth-year head coach Pinky Spruhan, the Maroons compiled an overall record of 3–7.