| Year: | 1921 |
| Team: | Penn Quakers |
| Sport: | football |
| Conference: | Independent |
| Record: | 4–3–2 |
| Head Coach: | John Heisman |
| Hc Year: | 2nd |
| Captain: | Rex Wray |
| Stadium: | Franklin Field |
The 1921 Penn Quakers football team was an American football team that represented the University of Pennsylvania as an independent during the 1921 college football season. In their second season under head coach John Heisman, the Quakers compiled a 4–3–2 record and outscored all opponents by a total of 164 to 135.[1] The team played its home games at Franklin Field in Philadelphia.