| Year: | 1921 |
| Team: | Ole Miss Rebels |
| Sport: | football |
| Conference: | Southern Intercollegiate Athletic Association |
| Short Conf: | SIAA |
| Record: | 3–6 |
| Conf Record: | 1–3 |
| Head Coach: | R. L. Sullivan |
| Hc Year: | 3rd |
| Stadium: | Hemingway Stadium |
| Bowl: | Bacardi Bowl |
| Bowl Result: | L 0–13 vs. Cuban Athletic Club |
The 1921 Ole Miss Rebels football team represented the University of Mississippi (Ole Miss) as a member of the Southern Intercollegiate Athletic Association (SIAA) during the 1921 college football season. Led by third-year head coach R. L. Sullivan, the Rebels compiled an overall record of 3–6, with a mark of 1–3 in conference play, and a loss in the Bacardi Bowl. Ole Miss played home games at Hemingway Stadium in Oxford, Mississippi.[1]