| Year: | 1921 |
| Team: | Oklahoma Sooners |
| Sport: | football |
| Conference: | Missouri Valley Intercollegiate Athletic Association |
| Short Conf: | MVIAA |
| Record: | 5–3 |
| Conf Record: | 2–3 |
| Head Coach: | Bennie Owen |
| Hc Year: | 17th |
| Off Scheme: | Single-wing |
| Captain: | Lawrence Haskell |
The 1921 Oklahoma Sooners football team represented the University of Oklahoma in the 1921 college football season. In their 17th year under head coach Bennie Owen, the Sooners compiled a 5–3 record (2-3 against conference opponents), finished in a tie for seventh place in the Missouri Valley Intercollegiate Athletic Association (MVIAA), and outscored their opponents by a combined total of 127 to 102.[1] [2]
No Sooners were recognized as All-Americans,[3] and end Howard Marsh was the only Sooner to receive all-conference honors.[4]