| Year: | 1921 |
| Team: | Ohio State Buckeyes |
| Sport: | football |
| Conference: | Big Ten Conference |
| Short Conf: | Big Ten |
| Conference2: | Ohio Athletic Conference |
| Short Conf2: | OAC |
| Record: | 5–2 |
| Conf Record: | 4–1 |
| Conf2 Record: | 1–1 |
| Head Coach: | John Wilce |
| Hc Year: | 9th |
| Captain: | Cyril E. Myers |
| Stadium: | Ohio Field |
The 1921 Ohio State Buckeyes football team represented Ohio State University in the 1921 Big Ten Conference football season. The Buckeyes compiled a 5–2 record while outscoring opponents 110–14. The 14 points allowed came in Ohio State's only losses. The Buckeyes' 1921 loss to remains their last loss to a team from the state of Ohio.[1]