| Year: | 1921 |
| Team: | Notre Dame Fighting Irish |
| Sport: | football |
| Conference: | Independent |
| Record: | 10–1 |
| Head Coach: | Knute Rockne |
| Hc Year: | 4th |
| Off Scheme: | Single-wing |
| Def Scheme: | 7–2–2 |
| Captain: | Eddie Anderson |
| Stadium: | Cartier Field |
The 1921 Notre Dame Fighting Irish football team represented the University of Notre Dame during the 1921 college football season, led by fourth-year head coach Knute Rockne.
Back John Mohardt led the team to a 10–1 record with 781 rushing yards, 995 passing yards, 12 rushing touchdowns, and nine passing touchdowns.[1] Grantland Rice wrote that "Mohardt could throw the ball to within a foot or two of any given space" and noted that the 1921 Notre Dame team "was the first team we know of to build its attack around a forward passing game, rather than use a forward passing game as a mere aid to the running game."[2]