| Year: | 1921 |
| Team: | Mississippi Normal Normalites |
| Sport: | football |
| Conference: | Independent |
| Record: | 3–4 |
| Head Coach: | O. V. Austin |
| Hc Year: | 1st |
| Stadium: | Kamper Park |
The 1921 Mississippi Normal Normalites football team was an American football team that represented Mississippi Normal College (now known as the University of Southern Mississippi) as an independent during the 1921 college football season. In their first year under head coach O. V. Austin, the team compiled a 3–4 record.[1]