| Team: | Minneapolis Marines |
| Year: | 1921 |
| League Place: | T-13th in APFA |
| Coach: | Rube Ursella |
| Stadium: | Nicollet Park |
| Previous: | none |
| No Prevseason: | true |
The 1921 Minneapolis Marines season was their inaugural season in the young American Professional Football Association (APFA). The team finished with a 1–3 record against league opponents,[1] and tied for thirteenth place in the league.
| Week | Date | Opponent | Result | |
|---|---|---|---|---|
| 1 | October 2 | at Chicago Cardinals | L 0–20 | |
| 2 | October 9 | Minneapolis Knights of Columbus | W 9–0 | |
| 3 | October 23 | at Green Bay Packers | L 6–7 | |
| 4 | October 30 | Columbus Panhandles | W 28–0 | |
| 5 | November 6 | at Rock Island Independents | L 3–14 | |
| 6 | November 11 | at Duluth Knights of Columbus | L 0–14 | |
| 7 | November 24 | Minneapolis All-Stars | W 7–0 | |
| 8 | December 4 | at Sioux City, Iowa | L 0–10 |