| Team: | Louisville Brecks |
| Year: | 1921 |
| Record: | 4–4–1 Overall 0–2 APFA |
| League Place: | T-18th APFA |
| Coach: | Austin Higgins |
| Stadium: | Eclipse Park |
| Previous: | none |
| No Prevseason: | true |
The 1921 Louisville Brecks season was their inaugural season in the young American Professional Football Association (APFA). The team finished 0–2 against league teams,[1] and tied for eighteenth place in the league.
| Week | Date | Opponent | Result | |
|---|---|---|---|---|
| 1 | October 2 | at Evansville Crimson Giants | L 0–21 | |
| 2 | October 16 | New Albany Calumet Indians | W 13–7 | |
| 3 | October 23 | Camp Knox Artillery | L 0–19 | |
| 4 | October 30 | Louisville Athletics | W 27–7 | |
| 5 | November 4 | Louisville Parkland | W 6–0 | |
| 6 | November 4 | New Albany Calumet Indians | W 20–0 | |
| 7 | November 4 | Camp Knox Artillery | L 0–13 | |
| 8 | December 4 | Columbus Panhandles | L 0–6 | |
| 9 | December 11 | Louisville Parkland | T 7–7 |