| Year: | 1921 |
| Team: | Indiana Hoosiers |
| Sport: | football |
| Conference: | Big Ten Conference |
| Short Conf: | Big Ten |
| Record: | 3–4 |
| Conf Record: | 1–2 |
| Head Coach: | Ewald O. Stiehm |
| Hc Year: | 6th |
| Captain: | Johnny Kyle |
| Stadium: | Jordan Field |
The 1921 Indiana Hoosiers football team represented the Indiana Hoosiers in the 1921 Big Ten Conference football season. The Hoosiers played their home games at Jordan Field in Bloomington, Indiana. The team was coached by Ewald O. Stiehm, in his sixth and final year as head coach.