| Year: | 1921 |
| Team: | Georgetown Blue and Gray |
| Sport: | football |
| Conference: | South Atlantic Intercollegiate Athletic Association |
| Short Conf: | SAIAA |
| Record: | 8–1 |
| Conf Record: | 1–0 |
| Head Coach: | Albert Exendine |
| Hc Year: | 8th |
| Captain: | Jack Flavin |
| Stadium: | Georgetown Field American League Park |
The 1921 Georgetown Blue and Gray football team was an American football team that represented Georgetown University as a member of the South Atlantic Intercollegiate Athletic Association (SAIAA) during the 1921 college football season. In their eighth season under head coach Albert Exendine, the Cardinals compiled a 8–1 record.