| Year: | 1921 |
| Team: | Erskine Seceders |
| Sport: | football |
| Conference: | Independent |
| Record: | 6–2 |
| Head Coach: | David W. Parrish |
| Hc Year: | 2nd |
| Captain: | Dode Phillips[1] |
The 1921 Erskine Seceders football team represented Erskine College as an independent during the 1921 college football season. Led by second-year head coach David W. Parrish, the Seceders compiled an overall record of 6–2.