| Team: | Columbus Panhandles |
| Year: | 1921 |
| Record: | 3–8 Overall 1–8 APFA |
| League Place: | 17th APFA |
| Coach: | Ted Nesser |
| Stadium: | Neil Field |
The 1921 Columbus Panhandles season was their second in the newly formed American Professional Football Association (soon to become the National Football League). The team failed to improve on their previous output of 2–6–2, winning only one league game.[1] They finished seventeenth in the league.
| Week | Date | Opponent | Result | |
|---|---|---|---|---|
| 1 | September 25, 1921 | at Akron Pros | L 14–0 | |
| 2 | October 2, 1921 | at Dayton Triangles | L 42–13 | |
| 3 | October 9, 1921 | at Buffalo All-Americans | L 38–0 | |
| 4 | October 16, 1921 | at Cleveland Indians | L 35–9 | |
| 5 | October 23, 1921 | at Chicago Cardinals | L 17–6 | |
| 6 | October 30, 1921 | at Minneapolis Marines | L 28–0 | |
| 7 | November 6, 1921 | Akron Pros | L 21–0 | |
| 8 | November 13, 1921 | Fort Wayne Pros | W 17–7 | |
| 9 | November 20, 1921 | at Rochester Jeffersons | L 27–13 | |
| 10 | December 4, 1921 | at Louisville Brecks | W 6–0 | |
| 11 | December 11, 1921 | Columbus Wagner Pirates | W 20–0 |