| Team: | Canton Bulldogs |
| Year: | 1921 |
| Record: | 8–3–3 Overall 5–2–3 APFA |
| League Place: | 4th APFA |
| Coach: | Cap Edwards |
| Stadium: | League Field |
The 1921 Canton Bulldogs season was their second completed in the young American Professional Football Association (APFA). The team improved on their previous output of 7–4–2, losing only two NFL games.[1] They finished fourth in the league.
| Week | Date | Opponent | Result | |
|---|---|---|---|---|
| – | October 2 | Massillon Blues | W 48–0 | |
| 1 | October 9 | Hammond Pros | T 7–7 | |
| 2 | October 16 | at Dayton Triangles | T 14–14 | |
| 3 | October 23 | Akron Pros | L 0–3 | |
| 4 | November 6 | Dayton Triangles | W 14–0 | |
| 5 | November 13 | at Cleveland Indians | W 7–0 | |
| 6 | November 20 | at Buffalo All-Americans | T 7–7 | |
| 7 | November 24 | at Akron Pros | W 14–0 | |
| 8 | November 27 | at Washington Senators | W 15–0 | |
| – | December 3 | at Union Quakers of Philadelphia | W 14–9 | |
| 9 | December 11 | at Chicago Staleys | L 0–10 | |
| – | December 15 | at Chicago Morris Supremes | W 19–0 | |
| – | December 17 | at Union Quakers of Philadelphia | L 0–34 | |
| 10 | December 18 | at Washington Senators | W 28–14 |