| Competition: | Liga Mexicana de Football Amateur Association |
| Season: | 1921-22 |
| Winners: | Liga Mexicana: Germania (1st title) Liga Nacional: Real España (2nd title) (Unrecognized titles) |
| Prevseason: | 1920-21 |
| Nextseason: | 1922-23 |
The 1921-22 season was the second edition divided into two leagues, the Liga Mexicana and Liga Nacional (en|Mexican League and National League). As happened the previous year, both tournaments and champions were not recognized by the organizing body.It was the last season before the leagues merged to create the first football federation (Federación de Foot-ball Asociación) and its new league called Campeonato de Primera Fuerza.
The 4 participating teams from Mexico City, Deportivo Internacional and Club Morelos withdrew, while Tranvías joined the league.All matches were played for 70 minutes and were played at Parque Asturias.
| Club | Pld | W | D | L | Pts | |
|---|---|---|---|---|---|---|
| Germania | 6 | 5 | 0 | 1 | 10 | |
| Asturias | 6 | 4 | 0 | 2 | 8 | |
| Club México | 6 | 1 | 1 | 4 | 3 | |
| Tranvías | 6 | 1 | 1 | 4 | 3 |
Only two teams participated, due to the withdrawal of Luz y Fuerza, Reforma and L'Amicale Française.To define the title, a single playoff match was played between Real España and América.