The 1921–22 Northern Football League season was the 29th in the history of the Northern Football League, a football competition in Northern England.
| Competition: | Northern League |
| Season: | 1921–22 |
| Winners: | South Bank |
| Matches: | 182 |
| Total Goals: | 640 |
| Prevseason: | 1920–21 |
| Nextseason: | 1922–23 |
The league featured 13 clubs which competed in the last season, along with one new club: