| Mode: | Basketball |
| Year: | 1921–22 |
| Prev Year: | 1920–21 |
| Next Year: | 1922–23 |
| Team: | Missouri Tigers |
| Conference: | Missouri Valley Conference |
| Short Conf: | MVIAA |
| Record: | 16–1 |
| Conf Record: | 15–1 |
| Hc Year: | 2nd |
| Champion: | Premo-Porretta National Champions |
The 1921–22 Missouri Tigers men's basketball team represented the University of Missouri in intercollegiate basketball during the 1921–22 season. The team finished the season with a 16–1 record[1] and was retroactively named the 1921–22 national champion by the Premo-Porretta Power Poll.[2] It was head coach Craig Ruby's second and final season coaching the team.[1]