| Competition: | Luxembourg National Division |
| Season: | 1921–22 |
| Winners: | CS Fola Esch (3rd title) |
| Matches: | 56 |
| Total Goals: | 271 |
| Highest Scoring: | Tricolore Muhlenweg 3–9 Sporting Club Luxembourg |
| Prevseason: | 1920–21 |
| Nextseason: | 1922–23 |
The 1921–22 Luxembourg National Division was the 12th season of top level association football in Luxembourg.
It was contested by 8 teams, and CS Fola Esch won the championship.