| Year: | 1918 |
| Team: | Case Scientists |
| Sport: | football |
| Conference: | Ohio Athletic Conference |
| Short Conf: | OAC |
| Record: | 3–5–2 |
| Conf Record: | 2–3–2 |
| Head Coach: | Pat Pasini |
| Hc Year: | 3rd |
| Stadium: | Van Horn Field |
The 1918 Case Scientists football team represented the Case School of Applied Science, now a part of Case Western Reserve University, during the 1918 college football season. The team's head coach was Pat Pasini.[1]
Due to the Spanish flu pandemic, Case played the and games behind locked gates with no fans and cancelled their games with and .[2] The game against was rescheduled from September 21 to midweek contest on November 6 and Hiram was added late in the year.[3]