| Election Name: | 1916 United States Senate election in Wyoming |
| Country: | Wyoming |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1911 United States Senate election in Wyoming |
| Previous Year: | 1911 |
| Next Election: | 1922 United States Senate election in Wyoming |
| Next Year: | 1922 |
| Election Date: | November 7, 1916 |
| Image1: | File:KENDRICK, JOHN B. GOVERNOR LCCN2016859134 (cropped).jpg |
| Nominee1: | John B. Kendrick |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 26,324 |
| Percentage1: | 51.47% |
| Nominee2: | Clarence D. Clark |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 23,258 |
| Percentage2: | 45.47% |
| Map Size: | 250px |
| U.S. Senator | |
| Before Election: | Clarence D. Clark |
| Before Party: | Republican Party (United States) |
| After Election: | John B. Kendrick |
| After Party: | Democratic Party (United States) |
The 1916 United States Senate election in Wyoming took place on November 7, 1916. Incumbent senator Clarence D. Clark, a Republican, sought re-election in his first popular election. He was opposed by John B. Kendrick, the incumbent governor of Wyoming and the Democratic nominee. Owing in part to President Woodrow Wilson's strong performance in the presidential election that year, Kendrick won a narrow but decisive victory over Clark, winning the first of three terms in the U.S. Senate.