| Election Name: | 1916 United States Senate election in Indiana |
| Country: | Indiana |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1911 United States Senate election in Indiana |
| Previous Year: | 1911 |
| Next Election: | 1922 United States Senate election in Indiana |
| Next Year: | 1922 |
| Election Date: | November 7, 1916 |
| Image1: | File:Harry S. New in 1924 (cropped).jpg |
| Nominee1: | Harry New |
| Party1: | Republican Party (United States) |
| Popular Vote1: | 337,089 |
| Percentage1: | 47.77% |
| Party2: | Democratic Party (United States) |
| Popular Vote2: | 325,588 |
| Percentage2: | 46.14% |
| Map Size: | 250px |
| U.S. Senator | |
| Before Party: | Democratic Party (United States) |
| After Party: | Republican Party (United States) |
The 1916 United States Senate election in Indiana took place on November 7, 1916. Incumbent Democratic U.S. Senator and Senate Majority Leader John W. Kern ran for re-election to a second term in office, he was defeated by Republican Harry New, a former Chairman of the Republican National Committee.
| Party | Candidate | Round 1 | Round 2 | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Votes | % | Transfer | Votes | % | |||||
| Republican | Harry New | 97,118 | 46.07% | + 3,981 | 101,099 | 52.05% | |||
| Republican | James Watson | 89,847 | 42.62% | + 3,273 | 93,120 | 47.95% | |||
| Republican | Arthur Robinson | 23,835 | 11.31% | BGCOLOR=lightgray | - 23,835 | Eliminated | |||
After losing the primary, Watson ran in the special election for Indiana's other Senate seat caused by the death of Senator Benjamin F. Shively, which he won over Indiana's other Senator Thomas Taggart. Watson would be sworn in as a U.S Senator 3 months before Senator-elect New's term began.
Kern died 5 months after leaving the U.S Senate.