| Year: | 1912 |
| Team: | Iowa State Cyclones |
| Sport: | football |
| Conference: | Missouri Valley Conference |
| Short Conf: | MVC |
| Record: | 6–2 |
| Conf Record: | 2–0 |
| Head Coach: | Clyde Williams |
| Hc Year: | 6th |
| Captain: | R. L. "Buck" Hurst |
| Stadium: | State Field |
| Champion: | MVC co-champion |
The 1912 Iowa State Cyclones football team represented Iowa State College of Agriculture and Mechanic Arts—now known as Iowa State University—as a member of the Missouri Valley Conference (MVC) during the 1912 college football season. Led by Clyde Williams in his sixth and final season as head coach, the Cyclones compiled an overall record of 6–2 with a mark of 2–0 in conference play, sharing the MVC title with Nebraska for the season consecutive year.[1] This would be the last time as of now that Iowa State has won a conference title.