| Year: | 1910 |
| Team: | Washington University Pikers |
| Sport: | football |
| Conference: | Missouri Valley Conference |
| Short Conf: | MVC |
| Record: | 3–4 |
| Conf Record: | 0–2 |
| Head Coach: | Frank Cayou |
| Hc Year: | 3rd |
| Captain: | Hartling |
| Stadium: | Francis Field |
| Prev: | 1909 |
The 1910 Washington University Pikers football team represented Washington University in St. Louis as a member of the Missouri Valley Conference (MVC) during the 1910 college football season. Led by third-year head coach Frank Cayou, the Pikers compiled an overall record of 3–4 with a mark of 0–2 in conference play, placing sixth in the MVC. Washington University played home games at Francis Field in St. Louis.