| Year: | 1910 |
| Team: | South Carolina Gamecocks |
| Sport: | football |
| Conference: | Independent |
| Record: | 4–4 |
| Head Coach: | John Neff |
| Hc Year: | 1st |
| Captain: | U. G. Desportes |
| Stadium: | Davis Field |
The 1910 South Carolina Gamecocks football team represented the University of South Carolina as an independent during the 1910 college football season. Led by first-year head coach John Neff, South Carolina compiled a record of 4–4.