| Year: | 1910 |
| Team: | Rose Polytechnic |
| Sport: | football |
| Conference: | Independent |
| Record: | 4–4 |
| Head Coach: | Heze Clark |
| Hc Year: | 3rd |
The 1910 Rose Polytechnic football team represented Rose Polytechnic Institute—now known as Rose–Hulman Institute of Technology—as an independent during the 1910 college football season. Led by third-year head Heze Clark, the team compiled a record of 4–4.