| Competition: | Primera División |
| Season: | 1906 |
| Winners: | Montevideo Wanderers |
| League Topscorer: | Rafael de Miquelenera (6) (Montevideo Wanderers) |
| Matches: | 30 |
| Total Goals: | 75 |
| Prevseason: | 1905 |
| Nextseason: | 1907 |
The 1905 Primera División was the 5th. season of top-flight football in Uruguay.
The tournament consisted of a round-robin championship. It involved six teams, and the champion was Montevideo Wanderers, being the first time that a club other than CURCC or Nacional won the Primera División.
As a curiosity during this championship, Nacional presented two teams to the competition, their official team and a second team formed by substitutes players, which was called "Nacional B". This was the first and only time in the editions of the Uruguayan Championships that a club participated with two teams.
| Team | City | Stadium | Capacity | Foundation | Seasons | Consecutive seasons | Titles | 1905 | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CURCC | Montevideo | 28 September 1891 | 5 | 5 | 3 | 1st | ||||||
| Intrépido | Montevideo | align=center | - | align=center | - | align=center | - | align=center | - | |||
| Nacional | Montevideo | Gran Parque Central | 7,000 | 14 May 1899 | 4 | 4 | 2 | 2nd | ||||
| Nacional "B" | Montevideo | Gran Parque Central | 7,000 | 14 May 1899 | align=center | - | align=center | - | align=center | - | align=center | - |
| Teutonia | Montevideo | 1896 | 5 | 5 | align=center | - | 4th | |||||
| Montevideo Wanderers | Montevideo | 15 August 1902 | 2 | 2 | align=center | - | 3rd |