| Competition: | Primera División |
| Season: | 1901 (2nd) |
| Winners: | CURCC (2º title) |
| League Topscorer: | Juan Pena (6) CURCC |
| Matches: | 20 |
| Total Goals: | 64 |
| Prevseason: | 1900 |
| Nextseason: | 1902 |
The 1901 Primera División was the second official championship of the Uruguayan football history.
The tournament consisted of a round-robin championship of all against all. It involved five teams, after allowing the entry of Club Nacional de Football to the competition. The champion was Central Uruguay Railway Cricket Club (CURCC).
| Team | City | Stadium | Capacity | Foundation | Seasons | Consecutive seasons | Titles | 1900 | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Albion | Montevideo | 1 June 1891 | 1 | 1 | align=center | - | 2nd | |||||
| CURCC | Montevideo | 28 September 1891 | 1 | 1 | 1 | 1st | ||||||
| Deutscher | Montevideo | 1896 | 1 | 1 | align=center | - | 4th | |||||
| Nacional | Montevideo | Gran Parque Central | 7,000 | 14 May 1899 | align=center | - | align=center | - | align=center | - | align=center | - |
| Uruguay Athletic | Montevideo | 10 August 1898 | 1 | 1 | align=center | - | 3rd |