19-Norandrosterone Explained

19-Norandrosterone, also known as 5α-estran-3α-ol-17-one, is a metabolite of nandrolone (19-nortestosterone) and bolandione (19-norandrostenedione) that is formed by 5α-reductase. It is on the list of substances prohibited by the World Anti-Doping Agency since it is a detectable metabolite of nandrolone, an anabolic-androgenic steroid (AAS).^[1] Consumption of androstendione products contaminated with traces of bolandione may also result in testing positive for nandrolone.^[2]

Traces of 19-norandrosterone may be naturally present in human urine. An experiment conducted on athletes showed that after a prolonged intense effort, the 19-norandrosterone concentration can be increased by a factor varying between 2 and 4,^[3] but another study failed to replicate the result.^[4] Concentration also increases in the urine of female athletes during menstruation.^[5] The consumption of edible parts of a non-castrated pig, containing 19-nortestosterone, has been shown to result in the excretion of 19-norandrosterone in the following hours, so athletes should prudently avoid meals composed of pig offal in the hours preceding doping tests.^[6] Consumption of boar meat, liver, kidneys and heart also increased 19-norandrosterone output.^[7]

See also

• Androsterone
• 19-Noretiocholanolone
• 5α-Dihydronandrolone
• 5α-Dihydronorethisterone

External links

• Testing for 19-norandrosterone
• Doping Control Procedures

Notes and References

1. Web site: THE 2007 PROHIBITED LIST INTERNATIONAL STANDARD . The World Anti-Doping Code . . 2009-05-14 . https://web.archive.org/web/20090410171528/http://www.wada-ama.org/rtecontent/document/2007_List_En.pdf . 10 April 2009 . dead .
2. Catlin DH, Leder BZ, Ahrens B, Starcevic B, Hatton CK, Green GA, Finkelstein JS . Trace contamination of over-the-counter androstenedione and positive urine test results for a nandrolone metabolite . JAMA . 284 . 20 . 2618–21 . 2000 . 11086369 . 10.1001/jama.284.20.2618. 29 December 2008 .
3. Le Bizec B, Monteau F, Gaudin I, André F . Evidence for the presence of endogenous 19-norandrosterone in human urine . J. Chromatogr. B . 723 . 1–2 . 157–72 . February 1999 . 10080643 . 10.1016/S0378-4347(98)00541-6.
4. Schmitt N, Flament MM, Goubault C, Legros P, Grenier-Loustalot MF, Denjean A . Nandrolone excretion is not increased by exhaustive exercise in trained athletes . Med Sci Sports Exerc . 34 . 9 . 1436–9 . September 2002 . 12218735 . 10.1097/00005768-200209000-00006 . free .
5. Van Eenoo P, Delbeke FT, de Jong FH, De Backer P . Endogenous origin of norandrosterone in female urine: indirect evidence for the production of 19-norsteroids as by-products in the conversion from androgen to estrogen . J. Steroid Biochem. Mol. Biol. . 78 . 4 . 351–7 . October 2001 . 11717005 . 10.1016/S0960-0760(01)00112-1. 19065089 .
6. Ayotte C . Significance of 19-norandrosterone in athletes' urine samples . Br J Sports Med . 40 . Suppl 1. i25–9 . July 2006 . 16799098 . 10.1136/bjsm.2006.028027 . 2657496.
7. Le Bizec B, Gaudin I, Monteau F, Andre F, Impens S, De Wasch K, De Brabander H . Consequence of boar edible tissue consumption on urinary profiles of nandrolone metabolites. I. Mass spectrometric detection and quantification of 19-norandrosterone and 19-noretiocholanolone in human urine . Rapid Commun. Mass Spectrom. . 14 . 12 . 1058–65 . 2000 . 10861987 . 10.1002/1097-0231(20000630)14:12<1058::AID-RCM991>3.0.CO;2-7 .