Bolandiol Explained

Bolandiol (INN, also known as 19-nor-4-androstenediol, estr-4-ene-3β,17β-diol, or 3β-dihydronandrolone) is an anabolic-androgenic steroid (AAS) that was never marketed.^[1] However, a dipropionate ester derivative, bolandiol dipropionate, has been marketed.^[2] Bolandiol and its dipropionate ester are unique among AASs in that they reportedly also possesses estrogenic and progestogenic activity.^{[3] [4]}

Bolandiol is on the World Anti-Doping Agency's list of prohibited substances,^[5] and is therefore banned from use in most major sports. It is a potential metabolic precursor to nandrolone.^[6] However, several clinical studies have concluded that bolandiol does not alter strength, body composition, or exercise performance.^{[7] [8]}

See also

• 4-Androstenediol
• 19-Nor-5-androstenediol
• 19-Nor-5-androstenedione
• Bolandione (19-nor-4-androstenedione)
• Bolenol (17α-ethyl-19-nor-5-androstenol)

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 899–.
2. Book: Hyde TE, Gengenbach MS . Conservative Management of Sports Injuries. 2007. Jones & Bartlett Learning. 978-0-7637-3252-3. 1100–.
3. Book: Action QA . Hormones: Advances in Research and Application . 2011 . 9 January 2012. ScholarlyEditions. 978-1-4649-2242-8 . 59–.
4. Attardi BJ, Page ST, Hild SA, Coss CC, Matsumoto AM . Mechanism of action of bolandiol (19-nortestosterone-3beta,17beta-diol), a unique anabolic steroid with androgenic, estrogenic, and progestational activities . The Journal of Steroid Biochemistry and Molecular Biology . 118 . 3 . 151–61 . February 2010 . 19941958 . 2831543 . 10.1016/j.jsbmb.2009.11.008 .
5. Web site: The World Anti-Doping Code: The 2012 Prohibited List . . 2012-07-17 . dead . https://web.archive.org/web/20120513020202/http://www.wada-ama.org/Documents/World_Anti-Doping_Program/WADP-Prohibited-list/2012/WADA_Prohibited_List_2012_EN.pdf . 2012-05-13 .
6. Dehennin L, Bonnaire Y, Plou P . Human nutritional supplements in the horse: comparative effects of 19-norandrostenedione and 19-norandrostenediol on the 19-norsteroid profile and consequences for doping control . Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences . 766 . 2 . 257–263 . January 2002 . 11824814 . 10.1016/S0378-4347(01)00506-0 .
7. Van Gammeren D, Falk D, Antonio J . The effects of supplementation with 19-nor-4-androstene-3,17-dione and 19-nor-4-androstene-3,17-diol on body composition and athletic performance in previously weight-trained male athletes . European Journal of Applied Physiology . 84 . 5 . 426–431 . May 2001 . 11417430 . 10.1007/s004210100395 . 13129479 .
8. van Gammeren D, Falk D, Antonio J . Effects of norandrostenedione and norandrostenediol in resistance-trained men . Nutrition . 18 . 9 . 734–737 . September 2002 . 12297208 . 10.1016/s0899-9007(02)00834-1 .