19-Epivoacristine Explained

19-Epivoacristine is an indole alkaloid found in different species of Tabernaemontana, such as Tabernaemontana dichotoma, as well as in Peschiera affinis.[1] It is also known as 20-epivoacangarine and 19-epi-voacangarine.[2]

Potential pharmacology

19-Epivoacristine may be a selective acetylcholinesterase (AChE) inhibitor in vitro.[3]

Chemistry

19-Epivoacristine can be prepared by potassium borohydride reduction of voacryptine.[4]

See also

Notes and References

  1. Lemos TL, Andrade CH, Guimarães AM, Wolter-Filho W, Braz-Filho RF . 19-Epivoacristine, an Iboga Alkaloid Isolated from Peschiera affinis . Journal of the Brazilian Chemical Society . 1996 . 7 . 2 . 123–126 . 10.5935/0103-5053.19960018. free .
  2. Web site: Tabernaemontana dichotoma Roxb.ex Wall . PhytoChemical Interactions DB (PCIDB) .
  3. Vieira IJ, Medeiros WL, Monnerat CS, Souza JJ, Mathias L, Braz-Filho R, Pinto AC, Sousa PM, Rezende CM, Epifanio Rde A . Two fast screening methods (GC-MS and TLC-ChEI assay) for rapid evaluation of potential anticholinesterasic indole alkaloids in complex mixtures . Anais da Academia Brasileira de Ciências . 80 . 3 . 419–26 . September 2008 . 18797794 . 10.1590/s0001-37652008000300003 . free .
  4. Book: 12 May 2014. The Alkaloids: Chemistry and Physiology . Elsevier. 83 . 9781483221960. Manske RH .

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