18S rRNA (adenine1779-N6/adenine1780-N6)-dimethyltransferase explained

18S rRNA (adenine^1779-N^6/adenine^1780-N^6)-dimethyltransferase
Ec Number:	2.1.1.183

18S rRNA (adenine¹⁷⁷⁹-N⁶/adenine¹⁷⁸⁰-N⁶)-dimethyltransferase (18S rRNA dimethylase Dim1p, Dim1p, ScDim1, m2(6)A dimethylase, KIDIM1) is an enzyme with systematic name S-adenosyl-L-methionine:18S rRNA (adenine¹⁷⁷⁹-N⁶/adenine¹⁷⁸⁰-N6)-dimethyltransferase.^{[1] [2] [3] [4] [5]} This enzyme catalyses the following chemical reaction

\rightleftharpoons 4 S-adenosyl-L-homocysteine + N⁶-dimethyladenine¹⁷⁷⁹/N⁶-dimethyladenine¹⁷⁸⁰ in 18S rRNA

DIM1 is involved in pre-rRNA processing.

Notes and References

1. Lafontaine D, Vandenhaute J, Tollervey D . The 18S rRNA dimethylase Dim1p is required for pre-ribosomal RNA processing in yeast . Genes & Development . 9 . 20 . 2470–81 . October 1995 . 7590228 . 10.1101/gad.9.20.2470 . free .
2. Lafontaine DL, Preiss T, Tollervey D . Yeast 18S rRNA dimethylase Dim1p: a quality control mechanism in ribosome synthesis? . Molecular and Cellular Biology . 18 . 4 . 2360–70 . April 1998 . 9528805 . 121492 . 10.1128/mcb.18.4.2360 .
3. Pulicherla N, Pogorzala LA, Xu Z, O Farrell HC, Musayev FN, Scarsdale JN, Sia EA, Culver GM, Rife JP . Structural and functional divergence within the Dim1/KsgA family of rRNA methyltransferases . Journal of Molecular Biology . 391 . 5 . 884–93 . September 2009 . 19520088 . 2753216 . 10.1016/j.jmb.2009.06.015 .
4. Lafontaine D, Delcour J, Glasser AL, Desgrès J, Vandenhaute J . The DIM1 gene responsible for the conserved m6(2)Am6(2)A dimethylation in the 3'-terminal loop of 18 S rRNA is essential in yeast . Journal of Molecular Biology . 241 . 3 . 492–7 . August 1994 . 8064863 . 10.1006/jmbi.1994.1525 .
5. O'Farrell HC, Pulicherla N, Desai PM, Rife JP . Recognition of a complex substrate by the KsgA/Dim1 family of enzymes has been conserved throughout evolution . RNA . 12 . 5 . 725–33 . May 2006 . 16540698 . 1440906 . 10.1261/rna.2310406 .