| Year: | 1888 |
| Team: | USC Methodists |
| Sport: | football |
| Conference: | Independent |
| Record: | 2–0 |
| Head Coach: | Henry H. Goddard & Frank H. Suffel |
| Hc Year: | 1st |
| Captain: | Will Whitcomb |
| Stadium: | USC campus |
| Prev Year: | none |
The 1888 USC Methodists football team was an American football team that represented the University of Southern California during the 1888 college football season. The team competed as an independent under coaches Henry H. Goddard and Frank H. Suffel, compiling a 2–0 record.