| Year: | 1888 |
| Team: | Penn Quakers |
| Sport: | football |
| Conference: | Independent |
| Record: | 9–7 |
| Head Coach: | Woody Wagenhorst |
| Hc Year: | 1st |
| Captain: | Tom Hulme |
The 1888 Penn Quakers football team was an American football team that represented the University of Pennsylvania during the 1888 college football season. In its first season under head coach Woody Wagenhorst, the team compiled a 9–7 record and was outscored by a total of 294 to 278.[1] Halfback Tom Hulme was the team captain. The team played its home games at the University Athletic Grounds located at 37th and Spruce Streets.