| Year: | 1888 |
| Team: | Penn Quakers |
| Sport: | football |
| Conference: | Independent |
| Record: | 9–7 |
| Head Coach: | Woody Wagenhorst |
| Hc Year: | 1st |
| Captain: | Tom Hulme |
The 1888 Penn Quakers football team was an American football team that represented the University of Pennsylvania during the 1888 college football season. In its first season under head coach Woody Wagenhorst, the team compiled a 9–7 record and outscored opponents by a total of to .[1] Halfback Tom Hulme was the team captain. The team played its home games at the University Athletic Grounds located at 37th and Spruce Streets.