| Election Name: | 1888 Missouri gubernatorial election |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1884 Missouri gubernatorial election |
| Previous Year: | 1884 |
| Next Election: | 1892 Missouri gubernatorial election |
| Next Year: | 1892 |
| Election Date: | November 6, 1888 |
| Nominee1: | David R. Francis |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 255,764 |
| Percentage1: | 49.36% |
| Nominee2: | Elbert Kimball |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 242,531 |
| Percentage2: | 46.81% |
| Map Size: | 270px |
| Governor | |
| Before Election: | Albert P. Morehouse |
| Before Party: | Democratic Party (United States) |
| After Election: | David R. Francis |
| After Party: | Democratic Party (United States) |
The 1888 Missouri gubernatorial election was held on November 6, 1888 and resulted in a victory for the Democratic nominee, Mayor of St. Louis David R. Francis, over the Republican candidate Elbert E. Kimball, Union Labor candidate Ahira Manring, and Prohibition candidate Frank M. Lowe.