There were six special elections to the United States House of Representatives in 1885 during the 48th and 49th Congresses.
|-| | Alfred M. Scales| | Democratic| 1857
1858
1874| | Incumbent resigned December 30, 1884, when elected Governor of North Carolina.
New member elected January 15, 1885.
Democratic hold.
Successor seated January 28, 1885.
Winner was already elected to the next term.| nowrap |
|-| | Jonathan Chace| | Republican| 1880| |Resigned January 26, 1885, when elected U.S. Senator.
New member elected February 5, 1885.
Republican hold.
Successor seated February 12, 1885.
Winner was already elected to the next term.| nowrap |
|}
|-| | James K. Jones| | Democratic| 1880| |Incumbent member-elect resigned during the previous Congress when elected U.S. senator.
New member elected September 7, 1885.
Democratic hold.
Successor seated December 7, 1885.| nowrap |
|-| | Reuben Ellwood| | Republican| 1882| | Incumbent died July 1, 1885.
New member elected November 3, 1885.
Republican hold.
Successor seated December 7, 1885.| nowrap |
|-| | Samuel S. Cox| | Democratic| 1856
1864
1868 | | Incumbent resigned to become U.S. Envoy Extraordinary and Minister Plenipotentiary to the Ottoman Empire.
New member elected November 3, 1885.
Democratic hold.| nowrap |
|-| | William A. Duncan| | Democratic| 1882| | Incumbent member-elected resigned during previous congress.
New member elected November 3, 1885.
Democratic hold.
Successor seated December 7, 1885.| nowrap |
|}