| Year: | 1881 |
| Team: | Penn Quakers |
| Sport: | football |
| Conference: | Independent |
| Record: | 0–5 |
| Head Coach: | None |
| Captain: | Gustavus Remak |
The 1881 Penn Quakers football team represented the University of Pennsylvania in the 1881 college football season. The team finished with a 0–5 record, managing to only score a single point.