See main article: 1880 United States presidential election.
| Election Name: | 1880 United States presidential election in South Carolina |
| Country: | South Carolina |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1876 United States presidential election in South Carolina |
| Previous Year: | 1876 |
| Next Election: | 1884 United States presidential election in South Carolina |
| Next Year: | 1884 |
| Election Date: | November 2, 1880 |
| Image1: | WinfieldScottHancock2 (cropped 3x4).jpg |
| Image1 Size: | x200px |
| Nominee1: | Winfield S. Hancock |
| Party1: | Democratic Party (United States) |
| Home State1: | Pennsylvania |
| Running Mate1: | William H. English |
| Electoral Vote1: | 7 |
| Popular Vote1: | 111,236 |
| Percentage1: | 65.51% |
| Image2 Size: | x200px |
| Nominee2: | James A. Garfield |
| Party2: | Republican Party (United States) |
| Home State2: | Ohio |
| Running Mate2: | Chester A. Arthur |
| Electoral Vote2: | 0 |
| Popular Vote2: | 57,954 |
| Percentage2: | 34.13% |
| Map Size: | 325px |
| President | |
| Before Election: | Rutherford B. Hayes |
| Before Party: | Republican Party (United States) |
| After Election: | James A. Garfield |
| After Party: | Republican Party (United States) |
The 1880 United States presidential election in South Carolina took place on November 2, 1880, as part of the 1880 United States presidential election. Voters chose 7 representatives, or electors to the Electoral College, who voted for president and vice president.
South Carolina voted for the Democratic nominee, Winfield Scott Hancock, over the Republican nominee, James A. Garfield. Hancock won the state by a margin of 31.38%.