| Election Name: | 1880 Boston mayoral election |
| Type: | Presidential |
| Ongoing: | no |
| Previous Election: | 1879 Boston mayoral election |
| Previous Year: | 1879 |
| Election Date: | December 14, 1880 |
| Next Election: | 1881 Boston mayoral election |
| Next Year: | 1881 |
| Image1: | Frederick O. Prince 5210004 015 024 (3x4e).jpg |
| Candidate1: | Frederick O. Prince |
| Party1: | Democratic Party (United States) |
| Popular Vote1: | 21,112 |
| Percentage1: | 50.68% |
| Candidate2: | Solomon B. Stebbins |
| Party2: | Republican Party (United States) |
| Popular Vote2: | 20,531 |
| Percentage2: | 49.29% |
| Mayor | |
| Before Election: | Frederick O. Prince |
| Before Party: | Democratic Party (United States) |
| After Election: | Frederick O. Prince |
| After Party: | Democratic Party (United States) |
The Boston mayoral election of 1880 saw incumbent mayor Frederick O. Prince (a Democrat) reelected to his fourth overall term, defeating Republican nominee Solomon B. Stebbins.
The Democratic Party renominated incumbent mayor Frederick O. Prince. The Republican Party nominated Solomon B. Stebbins.[1] The two had both been their party's nominees in the previous election.