| Club: | Rangers |
| Season: | 1880–81 |
| Mgrtitle: | Match Secretary |
| Manager: | John Wallace MacKay |
| Stdtitle: | Ground |
| Stadium: | Kinning Park |
| Chrtitle: | President |
| Chairman: | James Watson |
| Cup1: | Scottish Cup |
| Cup1 Result: | Second round |
| Prevseason: | 1879–80 |
| Nextseason: | 1881–82 |
The 1880–81 season was the seventh season of competitive football by Rangers.
Rangers played a total matches during the 1880–81 season.
All results are written with Rangers' score first.
| Date | Round | Opponent | Venue | Result | Attendance | Scorers | |
|---|---|---|---|---|---|---|---|
| 11 September 1880 | R1 | Govan Athletic | H | 4–1 | |||
| 2 October 1880 | R2 | Northern | H | 1–0 | 3,000 | ||
| 23 October 1880 | R3 | Partick Thistle | H | 3–0 | 1,000 | ||
| 13 November 1880 | R4 | Clyde | H | 11–0 | |||
| 18 December 1880 | R5 | Hurlford | A | 3–0 | |||
| 25 December 1880 | R6 | Dumbarton | H | 1–3 |