| Cup1 Result: | Second round (lost to Abercorn) |
| Highest Attendance: | 2,000 v. Abercorn (2 October 1880, Scottish Cup).[1] |
| Nextseason: | 1881–82 |
The 1880–81 season was Morton Football Club's fourth season in which they competed at a national level, entering the Scottish Cup.[2]
See main article: 1880–81 Scottish Cup.
See main article: Renfrewshire Cup.
1. Scratch Morton team.
2. One goal from each team was recorded as "disputed".
3. Pollok failed to appear.