| Club: | Hibernian |
| Season: | 1880–81 |
| League: | None |
| Cup1: | Scottish Cup |
| Cup1 Result: | R3 |
| Prevseason: | 1879–80 |
| Nextseason: | 1881–82 |
Season 1880–81 was the fourth in which Hibernian competed at a Scottish national level, entering the Scottish Cup for the fourth time.
Hibs reached the third round of the Scottish Cup, losing 5–3 to Edinburgh derby rivals Hearts. The match was played in the Powderhall area of Edinburgh.[1]
All results are written with Hibs' score first.
| Date | Round | Opponent | Venue | Result | Attendance | Scorers | |
|---|---|---|---|---|---|---|---|
| 9 October 1880 | R2 | Dunfermline | H | 3–1 | |||
| 23 October 1880 | R3 | Hearts | A | 3–5 | 5000 |