See main article: 1868 United States presidential election.
| Election Name: | 1868 United States presidential election in South Carolina |
| Country: | South Carolina |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1860 United States presidential election in South Carolina |
| Previous Year: | 1860 |
| Next Election: | 1872 United States presidential election in South Carolina |
| Next Year: | 1872 |
| Election Date: | November 3, 1868 |
| Image1: | Ulysses S Grant by Brady c1870-restored (3x4 crop).jpg |
| Nominee1: | Ulysses S. Grant |
| Party1: | Republican Party (United States) |
| Home State1: | Illinois |
| Running Mate1: | Schuyler Colfax |
| Electoral Vote1: | 6 |
| Popular Vote1: | 62,301 |
| Percentage1: | 57.93% |
| Nominee2: | Horatio Seymour |
| Party2: | Democratic Party (United States) |
| Home State2: | New York |
| Running Mate2: | Francis Preston Blair, Jr. |
| Electoral Vote2: | 0 |
| Popular Vote2: | 45,237 |
| Percentage2: | 42.07% |
| Map Size: | 325px |
| President | |
| Before Election: | Andrew Johnson |
| Before Party: | Democratic Party (United States) |
| After Election: | Ulysses S. Grant |
| After Party: | Republican Party (United States) |
The 1868 United States presidential election in South Carolina took place on November 3, 1868, as part of the 1868 United States presidential election. Voters chose 6 representatives, or electors to the Electoral College, who voted for president and vice president. This would be the first time in South Carolina's history where the popular vote was used in the state during the presidential election, with previous elections having used the state legislature.
South Carolina voted for the Republican nominee, General Ulysses S. Grant, over the Democratic nominee, former Governor of New York Horatio Seymour. Grant won the state by a margin of 15.86%.