| Election Name: | 1859 United States Senate election in Massachusetts |
| Type: | presidential |
| Ongoing: | no |
| Previous Election: | 1855 United States Senate special election in Massachusetts |
| Previous Year: | 1855 (special) |
| Next Election: | 1865 United States Senate election in Massachusetts |
| Next Year: | 1865 |
| Election Date: | January 11 and 12, 1859 |
| Votes For Election: | 40 members of the Massachusetts Senate 396 members of the Massachusetts House Majority vote of each house needed to win |
| 1Blank: | Senate |
| 2Blank: | Percentage |
| 3Blank: | House |
| 4Blank: | Percentage |
| Image1: | File:Colonel Henry Wilson (Massachusetts Senator, U.S. Vice President).jpg |
| Nominee1: | Henry Wilson |
| Party1: | Republican Party (US) |
| 1Data1: | 35 |
| 2Data1: | 87.5% |
| 3Data1: | 199 |
| 4Data1: | 84.69% |
| Senator | |
| Before Election: | Henry Wilson |
| Before Party: | Republican Party (United States) |
| After Election: | Henry Wilson |
| After Party: | Republican Party (United States) |
The 1859 United States Senate election in Massachusetts was held during January 1859. Incumbent Senator Henry Wilson, who had been elected in 1855 to fill the unexpired term of Edward Everett, was re-elected easily to a full term as a member of the Republican Party.
At the time, Massachusetts elected United States senators by a majority vote of each separate house of the Massachusetts General Court, the House and the Senate.
At the time, the Massachusetts legislature was dominated by a coalition of Republican Party and American Party supporters, united in opposition to slavery.
On January 11, the State Senate convened and re-elected Wilson overwhelmingly, with 35 votes.
On January 12, the House ratified the Senate result, electing Wilson to a full term in the U.S. Senate.