Massachusetts elected its members November 6, 1826. It required a majority for election, which was not met on the first vote in 3 districts requiring additional elections held March 5 and May 14, 1827.
| District | Incumbent | This race | ||||||
|---|---|---|---|---|---|---|---|---|
| Member | Party | First elected | Results | Candidates | ||||
| Daniel Webster | Anti-Jacksonian | 1812 1816 (Retired) 1822 | Incumbent re-elected. Incumbent resigned May 30, 1827, after being elected U.S. Senator, leading to a special election. | nowrap | ||||
| Benjamin W. Crowninshield | Anti-Jacksonian | 1823 | Incumbent re-elected. | nowrap | ||||
| John Varnum | Anti-Jacksonian | 1825 | Incumbent re-elected. | nowrap | ||||
| Edward Everett | Anti-Jacksonian | 1824 | Incumbent re-elected. | nowrap | ||||
| John Davis | Anti-Jacksonian | 1825 | Incumbent re-elected. | nowrap | ||||
| John Locke | Anti-Jacksonian | 1823 | Incumbent re-elected. | nowrap | ||||
| Samuel C. Allen | Anti-Jacksonian | 1816 | Incumbent re-elected. | nowrap | ||||
| Samuel Lathrop | Anti-Jacksonian | 1819 | Incumbent lost re-election. New member elected. Anti-Jacksonian hold. | nowrap | | |||
| Henry W. Dwight | Anti-Jacksonian | 1820 | Incumbent re-elected. | nowrap | | |||
| John Bailey | Anti-Jacksonian | 1823 (Special) | Incumbent re-elected. | nowrap | ||||
| Aaron Hobart | Anti-Jacksonian | 1820 | Incumbent retired. New member elected. Anti-Jacksonian hold. | nowrap | ||||
| Francis Baylies | Jacksonian | 1820 | Incumbent lost re-election. New member elected. Anti-Jacksonian gain. | nowrap | | |||
| John Reed Jr. | Anti-Jacksonian | 1812 1816 1818 | Incumbent re-elected. | nowrap | ||||