South Carolina elected its members February 12–13, 1823.
| District | Incumbent | This race | ||||||
|---|---|---|---|---|---|---|---|---|
| Member | Party | First elected | Results | Candidates | ||||
| Joel R. Poinsett | Democratic-Republican | 1820 | Incumbent re-elected. | nowrap | ||||
| James Hamilton Jr. | Democratic-Republican | 1822 (Special) | Incumbent re-elected. | nowrap | ||||
| Thomas R. Mitchell | Democratic-Republican | 1820 | Incumbent lost re-election. New member elected. Democratic-Republican hold. | nowrap | ||||
| Andrew R. Govan | Democratic-Republican | 1822 (Special) | Incumbent re-elected. | nowrap | ||||
| George McDuffie | Democratic-Republican | 1820 | Incumbent re-elected. | nowrap | ||||
| John Wilson | Democratic-Republican | 1820 | Incumbent re-elected. | nowrap | ||||
| Joseph Gist | Democratic-Republican | 1820 | Incumbent re-elected. | nowrap | ||||
| John Carter | Democratic-Republican | 1822 (Special) | Incumbent re-elected. | nowrap | ||||
| Starling Tucker | Democratic-Republican | 1816 | Incumbent re-elected. | nowrap | ||||