Indiana gained two seats in reapportionment following the 1820 United States census, and elected its members August 5, 1822.
Indiana's single at-large seat in the 17th Congress was empty at the time of the election, previous incumbent William Hendricks (Democratic-Republican) having resigned to run for Governor of Indiana. Jonathan Jennings (Jackson Democratic-Republican), elected to the new, was elected in the ensuing special election to fill the at-large district for the remainder of the 17th Congress.
| District | Incumbent | This race | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Member | Party | First elected | Results | Candidates | |||||
| None (District created) | New seat. New member elected. Democratic-Republican gain. | nowrap | |||||||
| None (District created) | New seat. New member elected. Democratic-Republican gain. Successor also elected the same day to finish the term in the expiring . | nowrap | |||||||
| William Hendricks | Democratic-Republican | 1816 | Incumbent resigned July 25, 1822 to run for Governor of Indiana. New member elected. Democratic-Republican gain. | nowrap | |||||