South Carolina gained one representative as a result of the 1810 census, increasing from 8 seats to 9. Its elections were held October 12–13, 1812.
| District | Incumbent | This race | ||||||
|---|---|---|---|---|---|---|---|---|
| Representative | Party | First elected | Results | Candidates | ||||
| Langdon Cheves | Democratic-Republican | 1810 | Incumbent re-elected. | nowrap | √ Langdon Cheves (Democratic-Republican) 65.3% John Rutledge Jr. (Federalist) 34.7% | |||
| William Lowndes | Democratic-Republican | 1810 | Incumbent re-elected. | nowrap | √ William Lowndes (Democratic-Republican) 84.5% Stephen Elliot (Federalist) 15.5%[1] | |||
| None (District created) | New seat. New member elected. Democratic-Republican gain. | nowrap | √ Theodore Gourdin (Democratic-Republican) James Ervin (Democratic-Republican) Benjamin Huger (Federalist) | |||||
| None (District created) | New seat. New member elected. Democratic-Republican gain. | nowrap | √ John J. Chappell (Democratic-Republican) 63.1% Edmund Bacon (Democratic-Republican) 29.5% John Bynum (Democratic-Republican) 7.4% | |||||
| None (District created) | New seat. New member elected. Democratic-Republican gain. | nowrap | √ David R. Evans (Democratic-Republican) Unopposed | |||||
| John C. Calhoun | Democratic-Republican | 1810 | Incumbent re-elected. | nowrap | √ John C. Calhoun (Democratic-Republican) Unopposed | |||
| Elias Earle | Democratic-Republican | 1805 (Special) 1806 (Lost) 1810 | Incumbent re-elected. | √ Elias Earle (Democratic-Republican) William Hunter (Democratic-Republican) | ||||
| Thomas Moore | Democratic-Republican | 1800 | Incumbent retired. New member elected. Democratic-Republican gain. | nowrap | √ Samuel Farrow (Democratic-Republican) James Duff (Federalist) | |||
| None (District created) | New seat. New member elected. Democratic-Republican gain. | nowrap | √ John Kershaw (Democratic-Republican) William Mayrant (Democratic-Republican) Charles Richardson (Democratic-Republican) | |||||