South Carolina elected its member October 8–9, 1810.
| District | Incumbent | This race | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Representative | Party | First elected | Results | Candidates | |||||
| Robert Marion | Democratic-Republican | 1804 | Incumbent retired. New member elected. Democratic-Republican hold. Incumbent then resigned December 4, 1810 and successor was also elected to finish the current term, see above. | nowrap | √ Langdon Cheves (Democratic-Republican) 89.2% Others 10.8% | ||||
| William Butler Sr. | Democratic-Republican | 1800 | Incumbent re-elected. | nowrap | √ William Butler Sr. (Democratic-Republican) Edmund Bacon (Democratic-Republican) Francisco Annone (Federalist) | ||||
| Robert Witherspoon | Democratic-Republican | 1808 | Incumbent retired. New member elected. Democratic-Republican hold. | nowrap | √ David R. Williams (Democratic-Republican) 94.4% Moses Glover (Federalist) 5.6% | ||||
| John Taylor | Democratic-Republican | 1806 | Incumbent lost re-election. New member elected. Democratic-Republican hold. | nowrap | √ William Lowndes (Democratic-Republican) 52.2% John Taylor (Democratic-Republican) 47.8% | ||||
| Richard Winn | Democratic-Republican | 1802 (Special) | Incumbent re-elected. | nowrap | √ Richard Winn (Democratic-Republican) 100% | ||||
| Joseph Calhoun | Democratic-Republican | 1807 (Special) | Incumbent retired. New member elected. Democratic-Republican hold. | nowrap | √ John C. Calhoun (Democratic-Republican) 72.2% John A. Elmore (Democratic-Republican) 27.8% Eastland(Federalist) | ||||
| Thomas Moore | Democratic-Republican | 1800 | Incumbent re-elected. | nowrap | √ Thomas Moore (Democratic-Republican) 100% | ||||
| Lemuel J. Alston | Democratic-Republican | 1806 | Incumbent retired. New member elected. Democratic-Republican hold. | nowrap | √ Elias Earle (Democratic-Republican) 58.0% William Hunter (Federalist) 42.0% | ||||